呼吸器感染症に対するCefotetan(YM09330)の臨床効果の検討 (Cefotetan(CTT,YM09330)<特集>)

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Seven patients were treated by cefotetan (CTT, YM09330), a new antibiotic, including three complicated with lung cancer (68 yrs, 68 yrs and 71 yrs males) one with mesothelioma (74 yrs, male) one bronchiectasis (56 yrs, female) one acute pneumonia (60 yrs, male) one mycoplasmal pneumonia (29 yrs, male). A method of administration was done by drip infusion, 1.0 g bid, except in case 2, 0.5 g per day as an outpatient was given. A period of administration was 7.5 days through 18 days, average 11.8 days, and the total given dose was 6.5 g through 18 g, average 11.5 g.<BR>This drug was bacteriologically effective in the case 2, <I>H. influenzae</I> pneumonia, in the case 5, P. aeruginosa was erradicated for a while but soon reappeared. Decrease of purulent sputum was observed in the case 1 and case 6 (bronchiectasis and lung cancer).<BR>The overall effective rate was 71.4%, excellent in 1, good in 2, fair in 2, unknown in 2. Abnormal laboratory findings and side effects which seemed to be caused by this drug were found in the case 1, in which, GOT, GPT and ALP value slightly rose and the patient complained of right hypochondria! pain. But all abnormalities normalized in a week after the stop of this drug.
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