Cefotetan(YM09330)の静脈内投与時のラットにおける器官形成期投与試験 (Cefotetan(CTT,YM09330)<特集>)

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Cefotetan (CTT, YM09330), a new cephamycin antibiotic, was administered intravenously to pregnant rats from day 7 through day 17 of pregnancy to evaluate possible teratogenicity and effects on the growth and functional development of the offspring. Doses were 100, 500 and 2, 000 mg/kg. Control animals received physiological saline. Of 35 to 39 dams of each group, about two thirds were sacrificed on day 20 of pregnancy and fetuses were examined for external, visceral and skeletal malformations. The remaining dams were allowed to deliver their young and pups were examined for growth, external differentiation and functional development during the lactation period. A part of the pups were examined for postweaning growth and functional development. In addition, some pups were mated within the same dose group after sexual maturation, and allowed to deliver their young to evaluate their reproductive capacity. In dams, there was a transient body weight decrease after the start of administration, and a decrease of the food intake and soft feces during administration, but there were no teratogenic effects on the fetuses or adverse effects on the postnatal growth, functional differentiation and the subsequent generation (F2). These findings suggest that cefotetan, like other cephem-type drugs, has not any teratogenic potentials and toxic effects on reproduction in rats.
公益社団法人日本化学療法学会の論文