Cefotetan(YM09330)の口腔組織内移行に関する研究 (Cefotetan(CTT,YM09330)<特集>)
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A new cephamycin derivative, cefotetan (CTT, YM09330) was applied to experimental study. Using SD strain rats, distribution of cefotetan in plasma, kidney, liver and in oral tissues such as submaxillary gland, alveolus, mandible, gingiva and lingua was assayed. Cefotetan was administered intravenously at a dose of 100mg/kg, and the distributions in plasma and tissues were assayed by the means of paper disc plate method.<BR>The concentration of cefotetan was highest in the kidney and followed in plasma and tissues ranking as liver, gingiva, lingua, submaxillary gland, mandible and alveolus. The pattern of cefotetan distribution in oral tissues were similar to the pattern of cefazolin and superior than those of cefmetazole in concentration and continuance.
- 公益社団法人 日本化学療法学会の論文
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