KW-1070(Fortimicin)の腎毒性にかんする実験的研究-2-利尿剤との併用による検討 (KW-1070(FORTIMICIN)<特集>)

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A study was made on the effects and recovery in kidney of rats between KW-1070 and amikacin. Single doses of KW-1070 and amikacin (160 and 320 mg/kg/day) were given to two groups each, and combined doses of the same amount of KW-1070 and amikacin together with diuretic furosemide (30mg/kg/day) were given to two other groups each. Functional and morphological comparisons were made and the results are given below.<BR>Renal toxicity for both the KW-1070 and amikacin groups was higher for the combined doses with furosemide than with the single doses. The changes in the KW-1070 groups, however, were milder than those in the amikacin groups.<BR>Recovery from kidney disorders was faster in the KW-1070 dose groups than in the amikacin dose groups.<BR>The serum level for both the KW-1070 and amikacin groups was higher for the combined doses with furosemide than with the single doses, while no difference was observed in kidney concentration between single doses and combined doses.
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