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An intramuscular injection of dibekacin (DKB) of more than 240 mg/kg induced remarkable acute renal damage in dehydrated rats deprived drinking water for 24hrs. When such rats previously received an oral administration of glucaron of more than 75 mg/kg, the induction of the dysfunction was aignificantly inhibited as measured the blood urea nitrogen contents. Accumulation of DKB in the blood and kindneys of rats receiving the repeated injections of the chemotherapeutic dose (130 mg/kg) was also inhibited by the combination with 600 mg/kg glucaron. In spite of such effects, antibacterial activity of DKB <I>in vivo</I> and <I>in vitro</I> was not quite influenced by the inhibitor.
公益社団法人日本化学療法学会の論文