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Ocularl toxicity of;spdium coliatin methanesulfonate (CLM) on visual organs was studied histopathologicalr, funduscopically and electroretinographically (ERG) in Wistar strain rats, rabbits and beagle dogs. CLM (25 mg, 40 mg/kg in rat; 80 mg/kg in rat, rabbit and beagle dog) dissolved in pyrogen free physiological saline was administered intravenously daily for 35 days except every Sunday. In the control group, the same volume of physiological saline was administered. Results were given as follows: 1. Throughout the experiment, no toxic symptoms and abnormal behaviors by CLM administration were observed. There was no significant changes of body weight gain in the groups treated with CLM. No deaths occurred in any of the groups. 2. ERG measured at the day after the final application of the drug was no remarkable difference between the CLM treated and control rats. 3. No statistic difference of histopathological alterations of eye ball was observed in any treated groups. 4. Toxicological influence of the CLM on the funduscopy of rabbits and beagle dogs was not observed. In consequence, CLM has no toxicological influences and specific effects on visual organs under these experimental conditions.
公益社団法人日本化学療法学会の論文