抗生物質の協力作用機構に関する研究-1-Cephaloridine耐性菌に対するCephaloridineとChloramphenicolの協力作用機構
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The 10 strains out of 50 gram negative rods, which were isolated at the clinical labolatory in the hospital of the Institute of Medical Science, University of Tokyo and determined as resistant against cephaloridine and sensitive to chloramphenicol by routine paper disk method, were highly resistant to cephaloridine (MIC≥1, 600 μg/ml) and relatively sensitive to chloramphenicol (MIC≤12. 5μg/ml).<BR>The synergistic effect of CER and small doses of CP was revealed in nine strains of these ten strains.<BR>In order to investigate the mechanism of this synergistic effects, β-lactamase activities were measured by microiodometric assay.<BR>It was suggested that the mechanism of this synergistic effect might not be due to leak out of β-lactamase, might be due to the stronger suppression of β-lactamase production than that of protein synthesis.
- 公益社団法人 日本化学療法学会の論文
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