外科領域における6059-Sの基礎的・臨床的検討 (6059-S<特集>)

概要

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Fundamental and clinical studies on 6059-S, a newly developed oxacephem derivative antibiotic, in the field of surgery were performed with the following results. 6059-S showed very excellent antibacterial activities against clinical isolates of E. coil and Klebsiella. The concentration of 6059-S in bile showed a marked fluctuation according to the amount of bile excretion and liver function. However, in patients with mild liver function damage, the distribution into bile was very good with a peak level seen 1 to 2 hours after administration. The concentration in ascites after intravenous injection of 0.5 g showed a peak concentration of 16.9μg/ml at 2% hours after administration and maintained high levels for over a long period. Thus, a good therapeutic response can be expected against intra-abdominal infections. When the drug was administered to 12 cases with surgical infections, the clinical response was excellent in 1 case, good in 8 cases, fair in 2 cases and poor in 1 case, showing an efficacy ratio of 75%. Especially, in 4 cases of intra-abdominal infection, good clinical response was obtained in all cases. No side effects nor adverse reactions on clinical laboratory findings attributable to the drug were observed.
公益社団法人日本化学療法学会の論文