Cefroxadine(CGP-9000)の毒性試験-1-急性毒性試験 (Cefroxadine(CGP-9000,CXD)<特集>)
スポンサーリンク
概要
- 論文の詳細を見る
Acute toxicity study of Cefroxadine (CGP-9000, CXD) was perfomed with mice, rats and rabbits, and following results were obtained.<BR>LD<SUB>50</SUB> were>13.5g/kg p. o. and s. c., >9g/kg i.p, in mice, >22.5g/kg p.o., >15g/kg s. c. and 6.00-6.40g/kg i. p. in rats, >10g/kg p. o. and >4g/kg i, p. in rabbits, and these LDE50 values were far higher than other cephalosporin derivatives. Symptoms were hypomortility, soft feces and diarrhea in p. o., s. c. and i. p. routes in mice, rats and rabbits, and futhermore piloelection, ataxia, salivation and lacrimation in i. p, route in rats. Autopsy and histopathological examination revealed slight degenerative tubular lesion of the kidney in mice, rats and rabbits.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
- DISPOSITION OF 7432-8 IN RATS (I)
- CLINICAL STUDIES ON T-1220 IN SURGICAL CASES
- CLINICAL STUDIES OF PIVALOYLOXYMETHYL D-α-AMINOBENZYL-PENICILLINATE HYDROCHLORIDE IN SURGICAL INFECTIONS
- STUDIES ON AC-1370
- Primary treatment with a combination of cyclophosphamide, vincristine, and dacarbazine for recurrent malignant pheochromocytoma: A case report.