泌尿器科領域におけるCefroxadine(CGP-9000)の基礎的,臨床的検討 (Cefroxadine(CGP-9000,CXD)<特集>)
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A new oral antibiotics, Cefroxadine (CGP-9000, CXD) was studied both bacteriologically and iclinically on the urological field, and the following conclusion were obtained.<BR>1) The effect of CXD against the growth curve of <I>E. coli</I> NIHJ JC-2 was studied with Biphotometer, used CEX as control. Both these drugs had almost equal ability in this functiowat 1/4, 1/2, 1, 2 or 4 MIC. Synergetic effect to ABPC against this strain was developed in both CXD and CEX. But in CXD, when ABPC was added at logarismic phase of this strain, this synergetic phenomenon was not observed.<BR>2) After oral administration of CXD 250 mg in the two male healthy volunteers, serum and urinary concentration pf this drug was measured with bioassay. The peak of serum CXD was 4.3μg/ml at 2 hour after administration. T1/2 was 0.7686 hour. Urinary concentration reached the peak at 2-4 hours after administration and urinary recovery rate for 6 hours was 52.2%.<BR>3) Bioautbgram of this urine was made. Both CXD and urine marked only one spot at Rf=0.25. So it seemed that there was no antibacterial substance in the urine except for CXD after oral administration.<BR>4) 30 cases of our out-patient clinic, 8 of acute simple cystitis rand 22 of chronic complicated UTI, were administrated 750 mg of CXD daily. The duration of adthinistration was 3 days at acute UTI and 5 days at chronic UTI. Overall effectiveness rate was 88% in the acute cases and 77% in the chronic ones. The MIC of CXD against strains isolated at this clinical trial was superior than that of CEX. In these patients, 2 cases complained nausea, skin itching and urticaria. But these symptoms were not so severe and diminished after 1 week without no treatment. Laboratory data was not changed attributed to this drug.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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