SulfamethoxazoleとTrimethoprim合剤の最適配合比に関する研究
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The optimum ratio of sulfamethoxazole (SMX) to trimethoprim (TMP) in the mixture for <I>in vitro</I> antibacterial activity to pathogenic aerobes was 24:1 and in contrast that to anaerobes was 1:24.<BR>The optimum ratio of SMX to TMP in the mixture for oral adminstration was considered to be 2-5:1 for aerobes and 1:64-128 for anaerobes. These values were estimated from the results in the present experiment and the data reported by many investigators on the level of drug concentration in blood or organs following the oral administration of the drugs.
- 公益社団法人 日本化学療法学会の論文
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