Cefaclorの免疫学的特性 (Cefaclor(CCL)<特集>)
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概要
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Some immunological properties of cefaclor (CCL) were examined in the experimental animals.<BR>1) In the three mouse strains tested, multiple injections of plain CCL emulsified with FREUND'S complete adjuvant failed to produce the antibodies of either class of IgE or IgG<SUB>1</SUB>. Under the same condition, plain Cephalothin (CET) and Penicillin-G (PCG) induced the difinite antibody response in some mice of any strains tested. Therefore, it is at least safe to state that the immunogenicity of CCL is much lower than those of these two antibiotics.<BR>2) Immunological cross-reactivity between CCL and other analogous antibiotics was determined using the protein conjugates of them as both immunogens and eliciting antigens. The results were not always consistent depending on the reaction systems such as the assay methods and origins of antibodies used (i. e., animal species and the timing for the antiserum preparation). But summarizing the results, the following comments would be presented. The cross-reactivity was highest between CCL and Cephalexin which was observed in all the reaction systems examined. Also, CET and Ampicillin cross-reacted with CCL in a number of reaction systems, but PCG and Cefazolin did not except for in a very few cases. So far as tested, plain CCL lacked eliciting antigenicity in the presensitized animals. Therefore cross-reactivity between plain CCL and other β-lactam antibiotics would be estimated to be much less than evaluated at the antibiotic-protein conjugate level.<BR>3) CCL failed to produce the <I>in vitro</I> direct COOMBS reactions even at <I>ca</I>. 5 mg/ml which was the highest concentration testable because of its low solubility.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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