産婦人科領域におけるCefaclorの基礎的・臨床的研究 (Cefaclor(CCL)<特集>)
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Cefaclor is a new oral semisynthetic cephalosporin antibiotic that is structurally related to cephalexin.<BR>1. Cefaclor was compared <I>in vitro</I> with cephalexin and cefatrizine against 221 organisms. Cefaclor and cephalexin were about equally active against <I>Staphylococcus aureus</I>. Cefaclor was the most active cephalosporin against <I>Esherichia coli, Proteus mirabilis</I>, and <I>Klebsiella pneumoniae</I>.<BR>2. Maternal serum levels of cefaclor after oral administration of a single 500mg dose to prognant women were 9.1μg/ml in peak level after 2 hours, 1.65μg/ml after 3 hours and trace after 8 hours respectively.<BR>The pattern of nasal blood levels was almost same as that of maternal serum levels.<BR>3. Cefaclor was administered to 32 cases of various infections, and clinical response was excellent in 8 cases, good in 20 cases and failure in 4 cases.<BR>No side effect or adverse reaction of cefaclor was observed. Cefaclor was considered to be an useful antibiotic of high safety.
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