泌尿器科領域におけるCefaclorの基礎的,臨床的検討 (Cefaclor(CCL)<特集>)

概要

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Laboratory and clinical evaluations were performed on a new oral cephalosporin, cefaclor, and the results were obtained as follows. 1. When cefaclor was administrated orally once at dose of 250mg and 500mg in 5 healthy fasting subjects by cross over method, the mean peak plasma levels were 9.7μg/ml and 13.4μg/ml, respectively. The mean plasma levels were undetectable after 6 hours. The urinary recovery rates within 6 hours were 69.0% and 65.2% respectively. 2. Fifty-six female patients with acute simple cystitis were treated with 750mg daily for 3 days. Excellent response was obtained in 48 patients and good response in 8, and the effectiveness rate was 100%. Five patients with chronic complicated cystitis were treated with 750mg or 1, 500mg daily for 5 or 7 days. Excellent response was obtained in 2 patients and poor response in 3, and the effectiveness rate was 40%. 3. At 106cells/ml inoculum size, MIC of cefaclor against most of the strains of E. coli isolated from those patients was ≤3.1μg/ml. 4. Gastric discomfort was complained in one out of 65 cases who were administrated cefaclor in this trial.
公益社団法人日本化学療法学会の論文