Cefaclorの基礎的,臨床的検討 (Cefaclor(CCL)<特集>)
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概要
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Laboratory and clinical studies on cefaclor were performed and the following results were obtained<BR>1) The <I>in vitro</I> antibacterial activity of cefaclor and cephalexin was compared against 36 clinical isolates of <I>E. coli</I> (19), <I>P. mirabilis</I> (5), <I>Citrobacter</I> (3), <I>S. epidermidis</I> (3), <I>Klebsiella</I> (2), <I>Enterobacter</I> (2) and <I>H. parainfluenzae</I> (2).<BR>Cefaclor was 2 to 8 fold more active than cephalexin against these clinical isolates.<BR>2) Cefaclor was clinically applied to 28 cases of bacterial infection, including 10 cases of respiratory infection, 11 cases of urinary tract infection, one case of acute cholecystitis and 6 cases of acute enteritis.<BR>The results obtained were good in 24 cases and poor in 4 cases. The effective rate was 85.7%.<BR>3) Transient nausea was seen in one case as a side effect. No abnomal laboratory findings were seen except in one case with transient slight increase in GOT and GPT values.
- 公益社団法人 日本化学療法学会の論文
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