Bacampicillinに関する基礎的・臨床的研究 (Bacampicillin<特集>)
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概要
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Laboratory and clinical studies were made on bacampicillin, a new orally well-absorbed derivative of amplicillin belonging to ampicillin esters.<BR>In the determination of tissue levels in rats, the absorption of bacampicillin as rapid as compared with ampicillin, and the peak value of the blood level was twice higher than that of ampicillin.<BR>Bacampicillin was orally administered to 24 patients with respiratory tract infections and 5 patients with urinary tract infections at the daily dose of 750 mg or 1000 mg in 3-or 4-divided portions. As the results, it was confirmed that bacampicillin was effective to respiratory tract infections caused by <I>H. influenzae</I> and <I>Str. pneumoniae</I> and <I>Str. pyogenes</I> and urinary tract infections caused by <I>E. coll</I>. No side effects were observed in all the 29 subjects. it was concluded that bacampicillin is more useful than ampicillin.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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