外科領域におけるMezlocillinの臨床試用成績 (Mezlocillin論文特集号)

概要

論文の詳細を見る
Mezlocillin, a new semisynthetic penicillin, has a broad spectrum antimicrobial activity. The authors investigated serum levels, urinary excretion rate, clinical effectiveness and side effects of the antibiotic. The results obtained are summarized as follows:<BR>Following an intravenous drip infusion of 2 g mezlocillin in a 200 ml of 5% glucose solution in 4 patients average peak level was 172.5μg/ml immediately after completion of intravenous infusion, decreasing rapidly thereafter within 4 hours. Urinary elimination of the agent was 988 mg (49.4%) within 4 hours.<BR>Mezlocillin was given to 27 patients with superficial infections, abscesses, acute peritonitis, biliary tract and postoperative wound infections, and urinary tract infections by means of an intravenous drip infusion.<BR>Response was excellent in 9 cases, good in 7, fair in 8 and poor in 3 (efficacy rate 88.9%).<BR>Side effects seen in 4 cases were skin eruption in 1 case, transient elevation of serum GOT and GPT in 2 cases and thrombocytopenia in 1 case.
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