FUNDAMENTAL AND CLINICAL STUDIES ON BILIARY TRACT INFECTIONS IN PATIENTS TREATED WITH APALCILLIN

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The characteristics of biliary excretion and clinical effects of apalcillin (APPC), a new semisythetic penicillin, were studied in patients with biliary tract infections, and the rerults were as follows: 1) Concentrations of APPC in gallbladder bile and tissue were measured after the one shot intra-venous injection of 1 g or 2g of APPC in patients operated for cholecystectomy. The concentrations of APPC in gallbladder bile and tissue after one shot intravenous injection of 1 g of APPC were averaged 1206.7 μg/ml and 43.1 μg/ml, respectively and after 2g of APPC averaged 1793.9 μg/ml and 73.4 μg/ml, respectively. 2) Bacteriological effects were obtained in 6 cases out of 10 cases detected causative organisms. MIC of APPC against these organisms were comparatively lower, and most of them were resistant to CBPC or SBPC. 3) The clinical effects were obtained in all 10 cases treated with drip infusion of 1g or 2g of APPC, and the responses were excellent in 2 cases and good in 8 cases. 4) Transient eruptions were observed in 2 cases after one shot intravenous injection, but no side effects and no abnormalities of laboratory findings were shown at treatment with drip infusion.
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