Sisomicinの聴器毒性とその安全性について (Sisomicin論文特集)
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The ototoxicity and safety of the aminoglycoside antibiotics Sisomicin and Gentamicin were compared and evaluated in guinea pigs of the Hartley strain receiving individual antibiotic at dose of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, respectively for 4 weeks, intramuscularly.<BR>1) At dose of 100 mg/kg/day, Sisomicin and Gentamicin caused extensive damage of the spiral organ and resulted frequently in extensive pinna reflex loss. The damage of the spiral organ was less severe in animals receiving Sisomicin than those receiving Gentamicin. The damage of the vestibular organ due to Sisomicin was less severe than that of the spiral organ. The difference in the damage of the spiral organ in Sisomicin and Gentamicin treated animals became less distinct, as the dose level becomes lower.<BR>2) At dose of 50 mg/kg/day, the damage of the spiral organ became reduced in Sisomicin treated animals and the pinna reflex loss did not occur or became limited to the highest frequency tested. The damage of the vestibular organ by Sisomicin also became reduced.<BR>3) At dose of 25 mg/kg/day, the injury of the spiral organ due to Sisomicin did not occur or was minimum. The loss of pinna reflex was not detected in any frequency by the differential frequency pinna reflex test in wide frequency range. The injury of the vestibular organ was infrequent and very mild.<BR>4) Basing on these results of the present animal test, the prospective dose (2 to 4mg/kg/day) for clinical application of Sisomicin is considered safe from ototoxicosis, if the antibiotic were not given at higher dose for longer period.
- 公益社団法人 日本化学療法学会の論文
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