新しいアミノ配糖体抗生物質Sisomicinに関する細菌学的評価 (Sisomicin論文特集)
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Sisomicin, a new aminoglycoside antibiotic was bacteriologically evaluated and compared with Gentamicin. The results are summarized as follows:<BR>1. In vitro studies of antibacterial spectrum and activity showed no significant differences between Sisomicin and Gentamicin.<BR>2. Sensitivity tests with clinical isolates did not show significant differences between Sisomicin and Gentamicin against <I>Staphylococci, Escherichia coli, Klebsiella pneumoniae, Enterobacter</I> and <I>Proteus sp.</I> However, <I>Pseudomonas aeruginosa</I> was more sensitive to Sisomicin, whereas <I>Serratia</I> was slightly more sensitive to Gentamicin.<BR>3. On the growth curve of <I>Pseudomonas aeruginosa, </I> no significant difference between Sisomicin and Gentamicin was observed. Comparing the speed of a 99.9% killing of <I>Pseudomonas aeruginosa</I> at 0.78 μg/ml or more with an inoculum size of 10<SUP>8</SUP> cells/ml, the killing curve showed a more rapid action with Sisomicin than with Gentamicin. Differences between both drugs were greater when an inoculum size of 10<SUP>6</SUP> cells/ml was used.<BR>4. Scanning electron-microscopy for morphological changes of <I>Pseudomonas aeruginosa</I> cells caused by the antibacterial action of Sisomicin revealed irregular cell surface and globular cells at MIC. With transmission electron-microscopy, perforations of the outer layers of cell walls were seen. These morphological changes are similar to those already reported with Gentamicin, Dibekacin and Tobramycin.<BR>5. Therapeutic effects of Sisomicin and Gentamicin were compared in experimentally infected mice. Sisomicin was more effective than Gentamicin in protecting animals infected with <I>Escherichia coli</I> and <I>Pseudomonas aeruginosa.</I> Both drugs were equally effective in <I>Serratia</I> infections. Interrelationship between inoculum size and ED<SUB>50</SUB> was studied on <I>Pseudomonas aeruginos</I>a. A larger inoculum resulted in a lower activity of both drugs, but Sisomicin was more active. The therapeutic effectiveness in relation to frequency and interval of administration was assessed. Comparison of the total dose administered showed that the therapeutic activity was lowest after a single dose. The longer the interval, the lower was the therapeutic activity. A similar tendency had been seen with Gentamicin.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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