外科領域におけるSisomicinの抗菌力,吸収,排泄,臓器移行性および臨床応用 (Sisomicin論文特集)

概要

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Laboratory and clinical investigations were carried out with Sisomicin and the following conclusions reached: 1. Antibacterial spectrum: Sisomicin has an excellent antibacterial activity against gram-positive bacteria, except Streptococcus and gram-negative bacteria. 2. Antibacterial activity against bacteria isolated from surgical specimen: Excellent antibacterial activity against Staphylococcus aureus, E. coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and others. Against Pseudomonas aeruginosa, Sisomicin was found to be superior to Gentamicin. 3. Serum leveles and urinary excretion: In healthy adults, mean peak serum level of 4.5 μg/ml was reached within 30 minutes after intramuscular injection of 50 mg.(cup-plate method using Moni-trol serum as standard solution). Urinary concentrations were highest within 1 hour after administration, averaging 167.0 μg/ml. Meanurinary recovery was 58.7% within 6 hours. 4. Tissue distribution: Twenty mg/kg applied intramuscularly to SD rats (n=3), gave highest drug concentrations in the kidney. Serum, lung, heart and spleen contained the drug in decreasing amounts. In the liver and brain only traces were measured. 5. Results of clinical trial: Sisomicin was applied to 8 patients with surgical infections. Results were "good" in 2, "fair" in 1 and "poor" in 5 cases. Adverse drug reactions were not observed or reported.
公益社団法人日本化学療法学会の論文