Cefoxitinの腎毒性にかんする実験的研究 (Cefoxitin論文特集号)

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Cefoxitin (600 or 3, 000 mg/kg/clay), cephalothin (3, 000 kg/clay) or cephaloridine (600 mg/kg day) was administered intravenously to rats for consecutive 21 clays, and their effects were examined on renal function and morphology.<BR>1) Rats given the higher dose of cefoxitin exhibited increased water consumption, hypotonic polyuria and a slight increase of urinary Al-P excretion, but no morphological changes were observed in the kidney. A lower dose of cefoxitin did not affect renal function and morphology.<BR>2) Rats treated with cephalothin showed increased water consumption, hypotonic polyuria and an increase in kidney weight. Histologically, the kidney showed very slight regeneration of proximal tubular epithelia after 7 days of treatment.<BR>3) When cephaloridine was given, rats displayed proteinuria, a considerable increase in urinary Al-P excretion and increase in kidney weight. Histological examination of the kidney revealed a slight to moderate regeneration of proximal tubular epithelia, appearance of basophilic granules in the tubules and desquamated epithelia in the tubules of outer medulla.<BR>4) The above results suggest that the renal effect of cefoxitin is practically negligible or extremely mild compared with those of other cephalosporins.
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