尿路感染症におけるT-1220の使用経験 (T-1220(Piperacillin)論文特集号)
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T-1220 was used for the treatment of urinary tract infections and the clinical efficacy was investigated.<BR>As the object of the study 17 cases of our clinic were selected, but they were complicated urinary tract infections having some basic diseases and 5 cases among them were the cases of indwelling catheter.<BR>Age : 22-75 years old. Male 11 cases and female 6 cases. As the dose and method of administration 2 g was administered twice a day to 10 cases, 4 g twice a day to 5 cases, drip infusion to 9 cases and intravenous injection to 8 cases. The duration of administration was 5-10 days and total dose of administration was 20-80 g.<BR>Among 11 cases of upper urinary tract infections, remarkably effective cases (excellent) were 3, effective cases (good) 5, ineffective cases 3 and the effective rate was 72.7%. Among 6 cases of lower urinary tract infections, remarkably effective cases (excellent) were 3, effective case (good) 1, ineffective cases 2 and the effective rate was 66.7%. In total, the effective rate was 70.6% (12 out of 17 cases).<BR>As bacteriological efficacy, the effective rate against <I>E. coli</I> was 100% (3 out of 3 strains), <I>Proteus</I> 66.7% (2 out of 3 strains) and <I>Pseudomonas</I> 50% (4 out of 8 strains).<BR>As for side effect mainly on the renal function (BUN, Creatinine), hepatic function (GOT, GPT, Al-P) and hematological findings (RBC, WBC, Hb) laboratory examinations were performed. However, any abnormal change by the effect of this drug was not observed and subjectively anything have to be specially mentioned was not observed.
- 公益社団法人 日本化学療法学会の論文
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