BACTERIOLOGICAL STUDIES ON CARFECILLIN, A NEW ORAL CARBENICILLIN

概要

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1. Antibacterial spectrum of carfecillin is the same as that of CBPC and I-CBPC, and its antibacterial activity is almost similar to that of CBPC, while it is a little weaker than that of I-CBPC especially against Gram-positive bacteria. 2. Sensitivity distribution of carfecillin to clinically isolated Staphylococcus, Escherichia, Proteus and Pseudomonas is almost the same to that of CBPC, and no correlation was noticed between two drugs. 3. Carfecillin was inactivated by β-lactamase extracted from penicillin resistant Escherichia isolated clinically. 4. Bactericidal action of carfecillin appears more rapidly to Staphylococcus than CBPC, and the action was recognized even at 1/4 MIC. To Escherichia, however, CBPC began bactericidal action more rapidly than carfecillin. 5. As to the treatment effect by oral administration of carfecillin in experimental infection of mice, I-CBPC exhibited most superior effect both in Escherichia and Pseudomonas. Though the treatment effect of carfecillin was a little inferior to I-CBPC, it was better than that of CBPC. As to the treatment time, immediately after the infection gave the best effect as well as 2 hours after. 6. As to the blood level and organs level in mice, the value of carfecillin was a little higher than that of CBPC, though it was lower than that of I-CBPC.
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