SUSCEPTIBILITY OF ANAEROBES TO FOSFOMYCIN
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概要
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Susceptibility of anaerobic bacteria isolated from clinical specimens to fosfomycin was studied by agar plate dilution technique.<BR><I>B. fragilis</I> (24 strains) were resistant to 12. 5, μg/ml or more of this drug. Though 5 strains of <I>Fusobacterium</I> including <I>F. nucleatum, F. russii</I> and <I>F. glutinosum</I> were sensitive to 12.5, μg/ml or less of the drug, 14 strains of <I>F. varium</I> were resistant to 25 μg/ml or more.<BR>Five strains of <I>Peptococcus</I> were sensitive to 1.56μg/ml or less, 29 strains of <I>Peptococcus</I>, however, were resistant to 6.25, μg/ml or more.<BR>In addition, influence of this drug on anaerobes in human fecal flora was studied. By 4 days of administration of 1 g per day, predominant organisms in fecal flora were changed from <I>B. fragilis</I> ss. <I>distasonis</I> to <I>B. fragillis</I> ss. <I>ovatus</I>.
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