STUDY ON CARBENICILLIN INDANYL SODIUM

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Concentration in the blood, excretion in the urine and clinical effects of carbenicillin indanyl sodium were studied, and the following results were obtained.<BR>1) Peak concentrations in serum of a single dose of 1, 000 mg of carbenicillin indanyl sodium given orally in 4 healthy adults right after rising were obtained 2 hours after administration with the range 4.75-9.45μg/ml. The absorption profile of this drug is similar to that of ampicillin.<BR>2) Serum concentrations of carbenicillin indanyl sodium given after meal were approximately one half of those obtained at fasting. From this result, administration 3 hours after meal is considered to be adequate in terms of timing of administration of this drug.<BR>3) Carbenicillin indanyl sodium was used in 23 patients with urinary tract infection. Since treatment was withdrawn in 2 patients due to side effect, therapeutic effect of the drug was assessed on 21 subjects. Eighteen patients responded markedly or moderately to the drug with the positive results of 86%. Side effects were observed in 4 cases, consisting of diarrhea in 2 cases, anorexia in one case and rash in one case. The side effects reported in the 2 patients whose treatment was discontinued were diarrhea and rash. Pre-and post-treatment laboratory tests were performed on 5 patients and no abnormality in GOT, GPT and Al-P was observed in all of the cases.
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