ANTIMICROBIAL ACTIVITY OF DKB AND MECHANISM OF ITS RESISTANCE AGAINST PSEUDOMONAS AERUGINOSA
スポンサーリンク
概要
- 論文の詳細を見る
We compared the antibacterial activity of DKB (3', 4'-dideoxykanamycin B) and that of gentamicin on 355 strains of <I>Pseudomonas aeruginosa</I>, and the mechanism of resistancl to DKB was studied.<BR>1) The newly introduced semisynthetic aminoglycoside antibiotics, <I>i. e</I>., 3', 4'-dideoxykanamycin B (DKB), 6'-N-methyl DKB (6'-Me-DKB) and amikacin have been found to be effective against <I>Pseudomonas aeruginosa</I> which are resistant to the known aminoglycoside antibiotics. <BR>2) DKB resistant <I>Pseudomonas aeruginosa</I> strains were isolated from clinical specimens before DKB was used.<BR>3) The strain resistant to DKB and 6'-Me-DKB disclosed that the enzyme catalyzing inactivation of both DKB and 6'-Me-DKB was mediated by an R factor.<BR>4) Enzymatic studies of inactivation reaction and chemical studies of the inactivated products indicated that DKB and 6'-Me-DKB were inactivated by acetylation of the 6' amino group of the drugs.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
- DISPOSITION OF 7432-8 IN RATS (I)
- CLINICAL STUDIES ON T-1220 IN SURGICAL CASES
- CLINICAL STUDIES OF PIVALOYLOXYMETHYL D-α-AMINOBENZYL-PENICILLINATE HYDROCHLORIDE IN SURGICAL INFECTIONS
- STUDIES ON AC-1370
- Primary treatment with a combination of cyclophosphamide, vincristine, and dacarbazine for recurrent malignant pheochromocytoma: A case report.