LABORATORY AND CLINICAL STUDIES ON CEPHRADINE (CED) IN OTO-RHINO-LARYNGOGICAL FIELD

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From the laboratory and clinical studies on cephradine (CED), the following results were obtained. 1) Activity of cephradine was measured by the plate dilution method on 117 strains isolated from pathological materials in our clinic. The peaks of MIC were 6.25 μg/ml with Staphylococcus aureus. Pseudomonas species were highly resistant to this antibiotic similarly to other cephalosporin antibiotics. 2) Tissue (tonsil and sinus membrane) and blood concentrations of cephradine.were determined 2 hours after oral administration in rabbits and humans to compare with those of cephalexin. In rabbits, concentration of cephradine in blood was 8. 13 μg/ml and in sinus membrane was 11.80 μg/g, while no evidence of significant tissue level was attained in tonsil. In humans, concentration of cephradine was 4.46 μg/ml in blood, 3.69 μg/g in sinus membrane, and 2.54μ9/gintonsil. 3) Cephradine was used clinically in 55 cases of ear, nose and throat infections, and its effective rate was 93.6%. 4) Adverse reaction was observed in 3 cases with the oral administration of cephradine ; diarrhea in one, anorexia and irritation of tongue in one, and sneezing in another one.
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