BASIC STUDY ON PIVAMPICILLIN AND ITS APPLICATION TO PULMONARY INFECTIOUS DISEASES
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概要
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Pivampicillin, a new synthetic penicillin, was studied basically and clinically, and the followings were revealed.<BR>1. Antimicrobial effect of pivampicillin to various strains was about same as that of ampicillin.<BR>2. The drug concentration in blood, after giving orally 500mg of pivampicillin was examined in 5 healthy male adults volunteers. The peak level was seen in 1 hour after administration, showing 8.2 mcg/ml on the average. Even in 6 hours after administration, 0.5mcg/ml of concentration was seen. Ampicillin was also examined with the same materials and methods. Then the peak level was seen in 4 hours after administration showing 2.3 mcg/ml on the average. Therefore, it became evident that pivampicillin is more easily absorbed than ampicillin, and urinary recovery rate was about proportional to the blood concentration.<BR>3. Regarding the concentration of pivampicillin in the various tissues of rats, the highest concentration was seen in the liver and kidneys. The concentration in the lungs was lower than that in blood.<BR>4. Eight cases with pulmonary infectious diseases were treated with 1, 000mg of pivampicillin. Favourable results were seen in 5 cases of them. The adverse reaction in the gastrointestinal tract was seen in all cases including the cases in which the drug was beneficial for the disease.<BR>One case could tolerate to this drug for 2 weeks. And yet, in the viewpoint of adverse reaction, it may be said that the clinical application of this dug is not favorable to continue for a long period.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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