ANIMAL EXPERIMENT FOR THE EFFECT OF GENTAMICIN ON BONE MARROW
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概要
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This experiment was performed on adult rabbits in order to detect bone marrow toxicity of gentamicin.<BR>Thirty minutes after a 40 mg single intramuscular injection of gentamicin into rabbits (13mg/kg), the maximum concentration of gentamicin in plasma reached to the level of 40mcg/ml. No abnormalities were detected in blood counts, bone marrow morphology and ferrokinetics after intramuscular injections of gentamicin at dose of 13mg/kg daily for 32 days. BUN and serum creatinine level did not vary from the normal range at the termination of the experiment.<BR>These results led us to assume that direct myelotoxicity is negligible in the clinical use of gentamicin.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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