FUNDAMENTAL STUDIES ON THE COMBINATION EFFECT OF JOSAMYCIN AND CHLORAMPHENICOL TOWARD <I>STAPHYLLOCOCCUS AUREUS</I>
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Combined effect of Josamycin (JM) and Chloramphenicol (CP) was examined by two dimentional tube dilution method, determination of growth curve in liquid medium, and crossed paper strip method toward <I>Staphylococcus aureus</I>. Effectiveness of the combination of the drugs was statistically judged.<BR>On JM resistant (JM<SUP>r</SUP>) strains, synergistic effect by the combination of both drugs was observed, whereas additive effect was obtained on JM sensitive (JM<SUP>s</SUP>) strains.<BR>Induced resistance to CP of CP<SUP>r</SUP> strains was inhibited by the addition of JM. Mutation frequency of JM<SUP>s</SUP> to JM<SUP>r</SUP> was also decreased by using both drugs.
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