THE STUDIES ON THE CONCENTRATION IN MYOCARDIUM OF METHYLPHENYLISOXAZOLYLPENICILLIN (MPI-PC), CEFAZOLIN (CEZ) AND LINCOMYCIN (LCM) IN MAN
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Examination of the concentration in myocardium was carried out at cardiac surgery. About 30 mg/ kg of MPI-PC, CEZ or LCM were given intramuscularly and then right auricle resected at the time of cannulation in open-heart surgery or left auricle resected at the time of mitral commissurotomy was examined. The serum concentration of the same time was also examined. To compare with those clinical results, examination of rat (100 mg/kg, i. m.) was carried out.<BR>1. MPI-PC<BR>Concentration in myocardium (M.) was a half of serum concentration (S.) about 2 hrs. after injection but M. was higher than S. 1 hr. after injection. M. was lower than that of the other two antibiotics. M. in rats was lower than M. in men.<BR>2. CEZ<BR>M. was equal to or a little lower than S. 1-4 hrs. after injection.<BR>M./S. in rats was approximately equal to that in men.<BR>3. LCM<BR>M. was a little lower than that of CEZ 1-2 hrs. after injection, but M./S. was approximately equal to that of CEZ.<BR>M. in rats was higher than M. in men.
- 公益社団法人 日本化学療法学会の論文
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