LABORATORY AND CLINICAL INVESTIGATIONS ON VISTAMYCIN (VSM)
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The laboratory and clinical investigations have been performed on Vistamycin (VSM), and the results were obtained as follows : <BR>(1) The antibacterial activity of VSM was slightly weaker than that of kanamycin (KM) against both Gram-negative bacilli and Gram-positive cocci. MIC was> 100 mcg/ml against <I>Pseudomonas</I>.<BR>(2) After an intramuscular injection of 500 mg of VSM, the one reached a peak of blood concentration in 30 minutes, while the other in 1 hour. The highest value was 27 mcg/ml on an average after 30 minutes, and the value was 8 mcg/ml after 6 hours.<BR>(3) VSM was administered to 3 cases of bacterial pneumonia and 9 cases of urinary tract infection. The effectiveness was obtained in 10 cases out of 12 cases (83.3%).<BR>(4) No remarkable side effect was observed.
- 公益社団法人 日本化学療法学会の論文
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