BIOLOGICAL STUDIES ON CHLORAMPHENICOL-GLYCINATE. I:ON THE ANTIBACTERIAL ACTIVITY
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概要
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1. Chloramphenicol-glycinate(CP-G) which has been researched as a water soluble chloramphenicolester in Italy indicated the antibacterial activity as well as chloramphenicol (CP) <I>in vitro</I> to 20 strains of CP sensitive bacteria and to 12 strains of CP resistant staphylococci. Suitable condition of microdetermination method of CP-G was studied. 2. In the examination <I>in vivo, </I> CP-G reveales longer survival time than that of CP, when they are injected intramuscularly to mice infected with <I>Diplococcus pneumonia</I> III strain.
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