ANTIMICROBIAL ACTIVITY OF DOXYCYCLINE (a-6-DEOXY-5OXYTETRACYCLINE) FOR STOCK STRAINS I SOLATED FROM URINARY TRACT INFECTIONS
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Minimal inhibitory concentration of doxycycline was determined by the plate dilution method for Enterobacteriaceae isolated from urinary tract, compared with that of tetracycline. This drug suppressed the growth of the isolates in same or lower concentration as tetracycline in vitro in exception of some strains of <I>Rettgerella.</I><BR>Almost all or ganisms subjected to be examined here were resistant strains, and the difference of its MIC from tetracycline was so little that it appeared insignificant to compare the both drugs in clinical effectiveness.<BR>It is convenient that the renal clearance is low and rather high serum level is maintained, but it will be less indicable to urinary tract infection because urinary concentration of the drug may not be overlooked in this infection.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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