USE OF DOXYCYCLINE HYDROCHLORIDE IN GYNECOLOGIC CLINIC
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1) <I>In vitro</I> MICs of doxycycline against TC-resistant <I>staphylococci, E. coli, </I> and <I>Pseudomonas</I> were fairly low as compared with TC. But, almost same value was obtained against <I>Proteus</I> and <I>Alkaligenes faecalis</I> strains.<BR>2) The concentra t ion of the antibiotic was higher in the blood of umbilical cord than in maternal blood.<BR>3) The amounts of the antibiotic excreted in milk and amniotic fluid were smaller than those of other antibiotics.<BR>4) No pigmentation of foetus bone was found as far as known from the observation of 3 cases at 8∼9th week of pregnancy who had received 200 mg of DOTC daily for 3∼5 days.<BR>5) Good results were obtained in patients with general gynecologic in f ections. Only 1 out of 4 patients with post-operative (cervical cancer) pyelonephritis showed favorable response.
- 公益社団法人 日本化学療法学会の論文
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