THIOPHENICOL, A CHLORAMPHENICOL DERIVATIVE: ITS USE FOR SEVERAL URINARY TRACT INFECTIONS

概要

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This study was undertaken to evaluate clinically thiophenicol (methylsulphenidol) in several urinary tract infections because of its high renal excretion. Absorption and urinary excretion of thiophenicol (TP) was examined on 3 male volunteers in comparison with chloramphenicol (CP), when 500 mg of TP or CP was orally administered as a single dosis. Urinary concentration of TP reached a peak at 3 hours after administration in three times of CP and recovery in urine was 35. 4% in average. In addition, excretion of this drug more prolonged than that of CP. Determination of minimal inhibitory concentrations to multiresistant gram-negative isolates from our cases of urinary tract infections revealed all the strains being more resistant than 62. 5 mcg/ml using plate dilution method, and showed this drug was not so effective as CP <I>in vitro.</I><BR>While clinical data given from 32 cases of several urinary tract infections showed its effectiveness in 78. 1% during 3 to 7 days treatment in 2 g daily dosis. This dyscrepancy between the clinical and laboratory results may be explained by high urinary concentration of this drug, and suggest that drug level in urine is not insignificant in management of urinary tract infection.<BR>Subjective untoward effects were rather mild but reversible bone marrow suppression was noticed in 2 cases after 7 days administration.
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