LABORATORY AND CLINICAL STUDIES ON ENDURACIDIN

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1. The minimal inhibitory concentrations of EDC for several kinds of bacteria obtained from patients were studied by plate dilution method. The results are as follows; 49 Strains.......... 0. 8 mcg/ml 15 Strains.......... 0. 2- 1 2. 5 mcg/ml MIC of EDC for 3 strains of Klebsiella, 4 strains of E. coli and 1 strain of Pseudomonas........... not less than 100 mcg/ml. 2. Blood levels and urinary excretions by intramuscular administrations of 1. 5 mg/kg of EDC were studied about 5 adults cases without renal impairment. Results are as follows. Blood level 1 hr........... 0. 28 mcg/ml 12 hr........... 0. 40 mcg/ml 3 hr........... 0. 39 mcg/ml 24 hr........... 0. 31 m c g/ml 6 hr........... 0. 37 mcg/ml Urinary excretion 0 - 6 hr........... 0 mg 12-24 hr........... 0. 54 mg 6-12 hr........... 0. 36 mg 3. The therapeutic effect of EDC on experimental Staphylococcal infections of mice were studied. The results indicated more effectiveness of EDC than erythromycin. 4. The binding rates of EDC with serum protein were studied by the method of ultracentrifugation. The results are as follows:. Binding rate: Human sera ..........67-72% Horse sera ..........84-86% 5. One case of acute bronchopneumonia and the other case of acute urinary infec t ion were treated with EDC and these cases indicated the effectiveness of EDC.
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