Clinical study on cefluprenam in obstetrics and gynecology
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概要
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We performed basic and clinical studies on cefluprenam (CFLP), a newly developed cephem antibiotics, in obstetric and gynecological fields and obtained the following results.<BR>1) The levels of CFLP in the serum of the uterine artery and cubital vein were 54.4μg/ml and 57.0μg/ml in the maximum, respectively at 40 min., after the beginning of CFLP 1g drip infusion for 30 min., and then declined gradually. The tissue concentrations of CFLP in genital organs ranged from 17.2μg/ml to 61.0μg/ml in the maximum after CFLP 1 g drip infusion, followed by a gradual decline, and remaining above 2μg/ml for about 5 hours. The concentration of CFLP transfered into retroperitoneal fluid was reached at the maximum level of 19.4μg/ml at 4 hours after CFLP 1 g drip infusion, then declined and remained at 11.1μg/ml for 12 hours.<BR>2) In our clinical study, CFLP was administered to 11 patients with obstetrical and gynecological infection. The clinical results were good in 9 cases and poor in 2 cases, showing the total effective rate of 81.8%. No clinical adverse reactions were observed in any cases.<BR>These results indicate that CFLP is effective for obstetrical and gynecological infection.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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