Laboratory and clinical studies on cefluprenam for surgical application
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概要
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The antibacterial activity and clinical efficacy of cefluprenam (CFLP), a new injectable cephalosporin, were evaluated in the treatment of surgical infections.<BR>1. Antibacterial activity<BR>CFLP showed potent activity against methicillin sensitive <I>Staphylococcus aureus</I> (methicillin, MIC:≤6.25 μg/ml), but the activity against methicillin resistant <I>S. aureus</I> (methicillin, MIC:≥12.5μg/ml) was inferior. The MIC<SUB>50</SUB> of CFLP against coagulase negative <I>Staphylococcus</I> and <I>Enterococcus</I> sp. were 6.25μg/ml. CFLP showed potent activity against gram-negative rods, <I>Escherichia coli, Klebsiella pneuroniae, Klebsiella oxytoca, Enterobacter cloacae, Enterobacter aerogenes</I> and <I>Citrobacter freundii</I>. Against <I>Serratia marcescens, Pseudomonas aeruginosa</I> and <I>Acinetobacter calcoaceticus</I>, the MIC<SUB>90</SUB> of CFLP were 12.5, 50 and 6.25μg/ml, respectively.<BR>2. Clinical study<BR>The clinical efficacy of CFLP in 12 patients: 4 with wound infection, 2 with cholangitis, 2 with phlegmon, 1 with cholecystitis, 1 with panperitonitis, 1 with intraabdominal abscess and 1 with periproctal abscess: was excellent in 3 and good in 9 cases. Neither subjective nor objective side effects were observed. Abnormal laboratory findings were observed with eosinophilia, leukopenia and elevation of BUN.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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