Inhibition of Phage Growth by an Antibiotic Rugulosin Isolated from Myrothecium verucaria:II. The Mechanism of Action

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The mechanism of anti-phage action of (-)rugulosin was investigated mainly using phage MS2. In the presence of the antibiotic, phage adsorption was not inhibited and phage-bacterium complexes did not remain in an antiserum-sensitive state. However, phage-bacterium complexes temporarily remained in a shear-sensitive state during the time immediately following phage infection and phage RNA penetrating into the host bacteria was decreased. The antibiotic also acted on preformed antiserum-and shear-resistant infective centers and inhibited the in uitro RNA synthesis by Qβ replicase. These results indicate that the mechanim of action of the antibiotic consists of at least 2 parts, i.e., the inhibition of the penetration of phage RNA into the host bacteria and some early intracellular reaction(s) for phage multiplication.
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