EFFECT OF GLICLAZIDE ON PROSTAGLANDIN I<SUB>2</SUB> FORMATION IN NORMAL AND STREPTOZOTOCIN-INDUCED DIABETIC ANIMALS
スポンサーリンク
概要
- 論文の詳細を見る
The effect of gliclazide, a hypoglycemic sulfonylurea, on the formation of prostaglandin (PG) I<SUB>2</SUB> by the aortic rings of normal and streptozotocin-induced diabetic animals was studied. In in vitro experiments, gliclazide (100-300 μg/ml) enhanced the spontaneous PGI<SUB>2</SUB> formation by the guinea-pig and rat aorta. Gliclazide also enhanced the transformation of both arachidonic acid and PGH<SUB>2</SUB> to PGI<SUB>2</SUB> in guinea-pig aorta, indicating that one of the main enhancing sites is the step of converting PGH<SUB>2</SUB> to PGI<SUB>2</SUB>. In ex vivo experiments, the formation of PGI<SUB>2</SUB> in the aorta of streptozotocin-diabetic rats was markedly reduced as compared with that of normal rats. An oral administration of gliclazide (100-300 mg/kg) significantly restored this reduced formation of PGI<SUB>2</SUB> without any effect on blood glucose level. This enhancing effect of gliclazide may be favorable to the treatment of diabetic microangiopathy.
- 社団法人 日本薬理学会の論文
著者
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KADOKAWA Toshiaki
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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Fujitani Buichi
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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SHIMIZU Masanao
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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MAEDA Junko
Research Laboratories, Dainippon Pharmaceutical Co. Ltd.
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TSUBOI Toshimichi
Research Laboratories, Dainippon Pharmaceutical Co. Ltd.
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Kadokawa Toshiaki
Research Laboratories Dainippon Pharmaceutical Co. Ltd.
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SHIMIZU Masanao
Research Laboratories, Dainippon Pharmaceutical Co. Ltd.
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FUJITANI Buichi
Research Laboratories, Dainippon Pharmaceutical Co. Ltd.
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