EFFECT OF GLUCOSE IN ISOPROTERENOL-INDUCED NECROTIC HEART UNDER ANOXIC PERFUSION
スポンサーリンク
概要
- 論文の詳細を見る
Studies of the isoproterenol-induced necrotic heart perfused under an anoxic condition were performed to determine the changes of metabolism and mechanical function. It was found that the increased concentration of glucose in a perfusion medium enabled the necrotic heart to preserve mechanical functions during anoxia. However, in the normal heart the protective effect of high glucose concentration was not significant. High glucose concentration enhanced anaerobic glycolysis in the necrotic heart during anoxia but had no significant effect on the levels of myocardial high energy phosphates.
- 社団法人 日本薬理学会の論文
著者
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SHIMIZU Masanao
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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YOSHIDA Kouichi
Research Laboratories, Dainippon Pharmaceutical Co., Ltd.
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TSUBOI Toshimichi
Research Laboratories, Dainippon Pharmaceutical Co. Ltd.
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OHSAWA Yoshiko
Research Laboratory, Dainippon Pharmaceutical Co., Ltd.
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ISHIKAWA Kohsaku
Research Laboratory, Dainippon Pharmaceutical Co., Ltd.
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SHIMIZU Masanao
Research Laboratories, Dainippon Pharmaceutical Co. Ltd.
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TSUBOI Toshimichi
Research Laboratory, Dainippon Pharmaceutical Co., Ltd.
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