PHARMACOKINETICS OF CEFETAMET PIVOXIL IN ELDERLY PATIENTS

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We investigated the pharmacoknetics of cefetamet pivoxil (CEMT-PI), a new oral cephem, in elderly patients with no apparent renal or hepatic deficiency. Four ambulatory patients (mean age 79.5 years, mean body weight 46.8kg), and 4 bedridden patients (mean age 83.5 years, mean body weight 37.5kg) received 500mg of CEMT-PI in the nonfasting state, and serum and urinary concentrations were determined. There was a marked delay in absorption in one patient with esophageal stenosis. Compared with 6 younger healthy volunteers, the increase and decrease in serum concentration were more delayed in the elderly patients. Urinay recovery was lower in the patients until 8 hours, but almost equal to that in the volunteers by 24 hours. These tendencies were more marked in the bedridden patients. Though there was a delay due to a protracted alimentary transfer time, absorption in the patients was good. Our data suggest that 1000mg cefetamet pivoxil b. i. d. is a recommendable dose for elderly patients.
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