Prospective, randomized, controlled trial of latamoxef and cefotetan as prophylactic antibiotics in elective colorectal operations.

概要

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The safety and efficacy of cefotetan (CTT) were compared to those of latamoxef (LMOX) for prophylaxis in patients undergoing elective colorectal surgery. Eighty-eight patients were randomised to receive either CTT or LMOX. An initial dose of 2 g i. v. was given in the operating room at the bigining of surgery, followed by 1 g i. v. 8-hourly for 4 days. Forty-three cases (including 3 subsequently withdrawn) were given CTT and 45 cases LMOX. The groups were comparable in age, sex, type of intervention and diagnosis. Eight patients (20.2%) in the CTT group and 8 (17.8%) in the LMOX group developed postoperative infections. The rate of postoperative infection was not significantly different. There was one patient with diarrhea and one with eruption in the CTT group, but none with side effects in the LMOX group. In the early postoperative period, abnormal liver function was noted in 30 patients (15 in each group). Postoperative renal dysfunction was observed in 1 patient in the CTT group and 2 in the LMOX group. The rates of side effects and abnormal laboratory findings were also not significantly different between the groups. This study suggests that CTT and LMOX are equally safe and effective prophylactic antibiotics for patients undergoing elective colorectal surgery.
公益社団法人日本化学療法学会の論文