Transfer of astromicin (ASTM) to the bronchoalveolar system.

概要

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We studied the transfer of astromicin (ASTM) to the bronchoalveolar system using bronchoalveolar lavage (BAL), and compared findings with previous results for cefmenoxime (CMX). The relation between inflammation and bronchoalveolar transfer was investigated. The subjects were 16 patients with various respiratory diseases: 7 with lung cancer, 5 with chronic bronchitis, 3 with interstitial pneumonia, and 1 with diffuse panbronchiolitis. BAL was performed 60 minutes after intramuscular injection of 200 mg of ASTM and the ASTM concentration in serum and BAL fluid (BALF), total protein and albumin were measured. The ASTM concentration was measured by high performance liquid chromatography and the following results were obtained. 1) The concentration of ASTM was 6.04-13.79 μg/ml in serum, and 0.02-0.21 μg/ml in BALF. 2) The mean value±standard deviation of ASTM concentration was 8.96±2.49μg/ml in serum, and 0.10±0.06μg/ml in BALF. 3) The transfer of ASTM to BALF was similar to that of CMX in the previous study, and smooth transfer to the bronchoalveolar system was recognized. 4) The ASTM/albumin ratio was higher in BALF than in serum. 5) In a case of idiopathic interstitial pneumonia, the level of ASTM in BALF was about ten times higher in the acute exacerbation phase than in the stable phase.
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