BASIC AND CLINICAL STUDIES ON HBK IN THE FIELD OF SURGERY
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概要
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HBK is a new aminoglycoside derivative from dibekacin. We examined bile concentration after intramuscular administration and sensitivity test against clinical isolates, and also we tried clinical studies in the field of surgery.<BR>1) Bile concentration of HBK after im. injection of 100mg showed at a peak 1.92μg/ml on 2 hours after administration.<BR>2) Following sensitivity test of aminoglycosides against clinical isolates, HBK was more sensitive against <I>P. aeruginosa</I> than other aminoglycosides.<BR>3) We administered it to 19 cases with surgical infections, and clinical efficacy obtained was excellent in 7, good in 10 and poor in 2 patients (effectiveness rate 89.5%).<BR>4) Side effect was seen in 1 case that complained severe pain at injection.
- 公益社団法人 日本化学療法学会の論文
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