STUDIES ON THE ANTIMICROBIAL ACTIVITIP AND CLINICAL EFFICACIES OF HBK

概要

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The antimicrobial activities of HBK were compared with those of GM, AMK and TOB against clinically isolated 526 strains of 28 species described below. Gram positive cocci: S. aureus, S. epidermidis, α-Streptococcus, β-Streptococcus and S. faecalis Gram negative bacilli: E. coli, Shigella, spp., S. typhi, Salmonella spp., K. pneumoniae, K. osytoca, C. freundii, S. marcescens, Enterobatter app., P.vulgaris, P. mirabilis, P. rettgeri, P. morganii, P. inconstans, P. aeruginosa, P. maltophilia, P. cepacia, V. parahaemolyticus, V alginolyticus, Aeromonas app., A. calcoaceticus, Flavobacterium app. and H. influenzae. In general, antimicrobial activities of HBK were almost the same as those of AMK, and somewhat inferior to GM and TOB. But GM and TOB showed high MIC values against some strains of S. aureus, S. epidermidis, P.vulgaris and P. aeruginosa, which were sensitive to HBK. HBK was administered to 10 cases with respiratory trtt infection and 2 cases with urinary tract infection. The clinical responses were good n 4 cases of respiratory tract infection and 2 cases of urinary tract infection and poor in 3 cases of respiratory tract infection. Remaining 3 cases of respiratory tract infection the clinical efficacies could not evaluated. As to the side effect, tinnitus and slight elevation of transaminase value was observed in each one case.
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