Distribution of chemotherapeutics in the prostatic tissue.
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概要
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Distribution of antimicrobial agents to the prostate has been investigated by using tissue removed at operation or by prostatic fluid. However, localization of the drugs in the prostatic tissue is not yet investigated in detail. In this study, we investigated the distribution of antimicrobial agents in the rat prostate by using microautoradiography.<BR>After subcutaneous administration of <SUP>14</SUP>C-cefmetazole (CMZ), prostatic gland was removed and frozen immediately in hexan-dry ice and was sectioned in a cryostat at 5μm thickness. Since CMZ is soluble in water, the section was lyophilized by the methods of STUMPF.<BR>The results of the present study indicate that <SUP>14</SUP>C-CMZ was distributed mainly to the connective tissue and interstitial tissue. The method employed in this study by us is an useful and reliable one for the investigation of distribution of chemotherapeutics in the prostatic tissue because each tissue can be directly and individually indicated.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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