EFFECT OF BAY o 9867 (CIPROFLOXACIN), A NEW QUINOLONE ANTIBACTERIAL AGENT, ON HUMAN FECAL FLORA
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BAY o 9867, a newly developed synthetic antibacterial agent, was orally administered to 20 healthy male volunteers (divided into two groups of 10 eath) 100 mg or 200 mg t. i. d. for 5 days. Changes in bacterial flora of whole feces and portion of feces, fecal levels of the drug, changes in the susceptibility of isolated microbes to the drug before, during and after the administration, adverse drug reactions were studied, and following results were obtained:<BR>1. Bacterial floras of whole feces showed marked effect of the drug on<I>Enterobacteriaceae</I>in both of the 100 mg dose group and 200 mg dose group. Trends of return to preadministration levels of bacterial count were seen 10 days after completion of the administration.<BR>Compared with preadministration levels, <I>Klebsiella</I>sp. detection rate increased and transient<I>Enterococcus</I>sp. negativity rate decreased in many cases. Scarcely any effect was observed on other strains and<I>C. difficile</I>was not detected at all in any cases throughout the whole course of the study.<BR>2. Changes in bacterial floras of portion of feces, were similar to those of whole feces. The portion of feces method, therefore, was considered useful as a simplified method of bacterial detection.<BR>3. Average fecal levels of the drug by bioassav method peaked one day after completion of the administration in both groups...248.9μg/g (100 mg group) and 553.7μg/g (200 mg group)...indicating the presence of dose response.<BR>4. The drug sensitivity to 621 strains isolated from feces in both groups obtained before, during and after the administration was compared, but no change was observed.<BR>5. One case each of heart burn, feeling of foreign body in the abdomen and diarrhea developed in the 100 mg groups, and one case each of abdominal discomfort and soft stool developed in the 200 mg group. Abnormal elevation of GOT value was observed in one case after treatment.
- 公益社団法人 日本化学療法学会の論文
公益社団法人 日本化学療法学会 | 論文
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